EGFR (mutant L858R) Antibodies

Antibodies that detect EGFR (mutant L858R) can be used in several scientific applications, including Western Blot, Immunohistochemistry and Immunocytochemistry. These antibodies target EGFR (mutant L858R) in Human samples. Our EGFR (mutant L858R) monoclonal and recombinant... Antibodies that detect EGFR (mutant L858R) can be used in several scientific applications, including Western Blot, Immunohistochemistry and Immunocytochemistry. These antibodies target EGFR (mutant L858R) in Human samples. Our EGFR (mutant L858R) monoclonal and recombinant monoclonal antibodies are developed in Mouse and... Antibodies that detect EGFR (mutant L858R) can be used in several scientific applications, including Western Blot, Immunohistochemistry and Immunocytochemistry. These antibodies target EGFR (mutant L858R) in Human samples. Our EGFR (mutant L858R) monoclonal and recombinant monoclonal antibodies are developed in Mouse and Rabbit. Find the EGFR (mutant L858R) antibody that fits your needs. Choose from 1 of 7 EGFR (mutant L858R) antibodies, which have been validated in experiments with 13 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody... Antibodies that detect EGFR (mutant L858R) can be used in several scientific applications, including Western Blot, Immunohistochemistry and Immunocytochemistry. These antibodies target EGFR (mutant L858R) in Human samples. Our EGFR (mutant L858R) monoclonal and recombinant monoclonal antibodies are developed in Mouse and Rabbit. Find the EGFR (mutant L858R) antibody that fits your needs. Choose from 1 of 7 EGFR (mutant L858R) antibodies, which have been validated in experiments with 13 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. This product is specific for EGFR (mutant L858R).

同义词

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR; Epidermal growth factor receptor; ERBB; ERBB1; erb-b2 receptor tyrosine kinase 1; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1